1. 国家自然科学基金面上项目(主持), TNF-α抗体治疗部分非感染性葡萄膜炎患者无效的机制及临床精准治疗研究，82471063, 70万元, 2025-2028
2. 国家自然科学基金面上项目(主持), 眼前房内诱导的调节性T细胞在角膜移植过程中的作用研究，82271129, 52万元, 2023-2026
3. 国家自然科学基金重点项目 (联合申请，合作单位项目主持人), 虹膜-睫状体-房水：角膜移植排斥防治的新途径及其机制研究，81530027, 273万元, 2015-2020
4. 国家自然科学基金面上项目(主持), Foxp3通过抑制c-Rel活性维持T调节细胞免疫抑制功能的分子机制研究，81471554, 71万元, 2014-2018
5. 中国科学院百人计划项目(主持), 100万元, 2014-2017
6. 深圳市基础研究重点项目(主持), 非编码RNA在糖尿病发病过程中的作用及机制研究，JCYJ20170413165432016, 200万元, 2017-2020
7. 深圳市孔雀人才技术创新项目(主持)，利用小分子多肽靶向IL-23在治疗自身免疫性疾病中的应用，KQJSCX20160301140901，100万元, 2016-2018
8. 深圳市基础研究自由探索项目(主持), 靶向c-Rel治疗类风湿性关节炎的研究，JCYJ20140610151856705, 30万元, 2014-2016
9. 深圳市基础研究自由探索项目(主持), MicroRNA-21在I型糖尿病发病过程中所起作用及机制的研究，JCYJ20130401170412298, 15万元, 2013-2015
10. 深圳市基础研究自由探索项目(主持), 靶向miR-122降低角膜移植排斥风险的研究，JCYJ20160531185449995, 30万元, 2016-2018
11. 青岛市科技惠民项目(主持)，角膜移植免疫排斥防治新方法的研发，21-1-4-rkjk-11-nsh, 50万元，2021-2022
12. 广东省基础研究自由探索项目(主持), MicroRNA-21 在1 型糖尿病发病过程中所起作用及机制的研究，B2013B021800165, 5万元, 2013-2016
1. Liu R, Liu C, He X, Sun P, Zhang B, Yang H, Shi W, Ruan Q*. MicroRNA-21 promotes pancreatic β cell function through modulating glucose uptake. Nat Commun，2022, 13(1):3545.
2. Ruan Q, Kameswaran V, Tone Y, Li L, Liou HC, Greene MI, Tone M, Chen YH. Development of Foxp3(+) regulatory t cells is driven by the c-Rel enhanceosome. Immunity. 2009, 31(6):932-40,
3. Ruan Q, Kameswaran V, Zhang Y, Zheng S, Sun J, Wang J, Devirgiliis J, Liou HC, Beg AA, Chen YH. The Th17 Immune Response Is Controlled By A c-Rel-ROR-RORrT Transcriptional Axis. J Exp Med. 2011, 208(11): 2321-33.
4. Ruan Q, Wang T, Kameswaran V, Wei Q, Johnson DS, Matschinsky F, Shi W, Chen YH. The microRNA-21−PDCD4 axis prevents type 1 diabetes by blocking pancreatic β cell death. PNAS. 2011; 108(29):12030-5.
5. Ruan Q, Zheng SJ, Palmer S, Carmody RJ, Chen YH. Roles of Bcl-3 in the Pathogenesis of Murine Type 1 Diabetes. Diabetes. 2010, 59(10):2549-57.
6. Ruan Q, Wang P, Wang T, Qi J, Wei M, Wang SW, Fan TT, Johnson DS, Wan XC, Shi WY, Sun HH, Chen YH*. MicroRNA-21 Regulates T Cell Apoptosis by Directly Targeting the Tumor Suppressor Gene Tipe2. Cell Death & Disease, 2014, 5: e1095.
7. Bian J, Wang T, Sun J, He X, Wu Z, Zhang S, Chi H, Fan T, Wang S, Shi W, Ruan Q*. Targeting NF-κB c-Rel in regulatory T cells to treat corneal transplantation rejection. Am J Transplant. 2021, 21(12):3858-3870.
8. Ruan QG, Wang CY, Shi JD, She JX. Expression and Alternative Splicing of the Mouse Autoimmune Regulator Gene (Aire). J Autoimmun. 1999, 13:307.
9. He X, Liu R, Fan T, Huang X, Wu C, Su W, Wang T, Ruan Q*. Treating Autoimmune Diseases by Targeting IL-23 with Gene-Silencing Pyrrole-Imidazole Polyamide. J Immunol. 2020, 204(8):2053-2063.
10. Bian J, Liu R, Fan T, Liao L, Wang S, Geng W, Wang T, Shi W, Ruan Q*. miR-340 Alleviates Psoriasis in Mice through Direct Targeting of IL-17A. J Immunol. 2018; 201(5):1412-1420.
11. Ruan QG, Tung K, Eisenman D, Setiady Y, Eckenrode S, Yi B, Purohit S, Zheng WP, Zhang Y, Peltonen L, She JX. The autoimmune regulator directly controls the expression of genes critical for thymic epithelial function. J Immunol. 2007, 178(11):7173-7180.
12. Zheng Q, Liu R, Jiang B, Sun J, Wang T, Ruan Q*. NF-κB c-Rel Is a Potential Therapeutic Target for Acute Corneal Transplant Rejection. Invest Ophthalmol Vis Sci. 2023; 64(14):16.
13. Sun J, Wang T, Bian J, Shi W, Ruan Q*. Immune tolerance induced in the anterior chamber ameliorates corneal transplant rejection. Clin Immunol. 2023, 257:109797.
14. Fan T, Wang S, Yu L, Yi H, Liu R, Geng W, Wan X, Ma Y, Cai L, Chen YH, Ruan Q*, Treating psoriasis by targeting its susceptibility gene Rel，Clin Immunol. 2016; 165:47-54.
15. Zhao W, He X, Liu R, Ruan Q*. Accelerating corneal wound healing using exosome-mediated targeting of NF-κB c-Rel. Inflamm Regen. 2023; 43(1):6.
16. Sun J, Liu R, He X, Bian J, Zhao W, Shi W, Ruan Q*. MicroRNA-21 Regulates Diametrically Opposed Biological Functions of Regulatory T Cells. Front Immunol. 2021, 12:766757.
17. Bian J, Wang K, Wang Q, Wang P, Wang T, Shi W, Ruan Q*. Dracocephalum heterophyllum (DH) Exhibits Potent Anti-Proliferative Effects on Autoreactive CD4+ T cells and Ameliorates the Development of Experimental Autoimmune Uveitis. Front Immunol. 2020, 11:1-18.
18. Liu R, He X, Geng W, Wang T, Ruan Q*. Loss of TIPE2 Has Opposing Effects on the Pathogenesis of Autoimmune Diseases. Front Immunol. 2019; 10: 2284.
19. Carmody RJ, Ruan Q, Palmer S, Hilliard B, Chen YH. Negative Regulation of Toll-Like Receptor Signaling by NF-kB p50 Ubiquitination Blockade. Science. 2007, 317(5838):675-678.
