河南大学医学院官方网站

黄永伟

博士、副教授、博导
黄永伟

黄永伟,男,博士,副教授,化学学科和生物学科博士生导师, 河南大学基础医学院纳米医学光子学实验室主任,河南省杰出青年基金获得者, 河南省高校科技创新人才, 河南省高校科技创新团队带头人。2009年7月毕业于中国科学院国家纳米科学中心,获理学博士学位,同年进入河南大学基础医学院任教,主要从事有机小分子诊疗剂制备和性能评估研究。以第一作者或通讯作者在Adv. Mater.(影响因子:30.8),Angew. Chem. Int. Ed.(影响因子:15.3),Adv. Funct. Mater.(影响因子:18.8),Small (影响因子:13.3),Biomaterials(影响因子:12.3)等国际期刊上发表了SCI收录论文27篇(其中SCI一区20篇,TOP期刊22篇),论文引用1200余次。目前,主持国家自然科学基金4项,主持河南省杰出青年基金项目、河南省高校科技创新团队项目、河南省高校科技创新人才基金、河南省自然科学基金、中国博士后科学基金(一等资助和特别资助)、河南大学一流学科培育项目等省厅级项目8项,资助金额总计625万元。以第一发明人授权国家发明专利8项,以第一完成人获得河南省科技进步奖叁等奖1项,河南省教育厅科技进步奖壹等奖1项,河南省自然科学学术论文壹等奖2项,贰等奖3项。联系方式:13663783742,E-mail:huangyw@henu.edu.cn。

一、 承担的科研项目(均为项目负责人)

(16) 非共价键作用力介导苝酰亚胺实现肺特异性分布及抗肺癌性能,国家自然科学基金(编号:22175055,2022.01–2025.12,资助金额78万)。

(15) 苝酰亚胺衍生物纳米光诊疗剂构建及其抗非小细胞肺癌性能,国家自然科学基金(编号:

U1904150,2020.01‒2022.12,资助金额57.6万)

(14) 手性烷基链调控下的苝酰亚胺衍生物自组装结构气敏传感性能研究,国家自然科学基

金(编号:21572045,2016.01–2019.12,资助金额78万)。

(13) 苝酰亚胺衍生物一维单晶纳米结构气敏传感性能的研究,国家自然科学基金(编号:

21202036,2013.01–2015.12,资助金额25万)。

(12) 苝酰亚胺衍生物诊疗剂的制备及其抗肺癌性能,河南省杰出青年基金(212300410003,2021.01–2023.12,50万)。

(11) 苝酰亚胺衍生物诊疗剂,河南省高校科技创新团队项目(21IRTSTHN002,2021.01–2023.12,50万)。

(10) 多级次有机共轭聚合物纳米结构材料,河南大学一流学科培育项目(编号:2018YLZDJL02,2019.04–2021.04,资助金额140万)。

(9) 手性烷基链调控下的苝酰亚胺衍生物聚集体气敏传感性能的研究,河南省高校科技创新人才项目(编号:16HASTIT008,2016.01–2018.12,资助金额 60 万)。

(8) 含线型葡萄糖苷的手性苝酰亚胺衍生物组装体气敏传感性能研究,河南省自然科学基金(编号:162300410017,2017.01–2018.12, 资助金额10万元)。

(7) 手性烷基链调控下的苝酰亚胺衍生物气敏传感性能研究,中国博士后科学基金(特别资助,编号:2015T80767,2015.09–2016.09,资助金额22.5万)。

(6) 苝酰亚胺衍生物单晶纳米结构的制备及其气敏传感性能的研究,中国博士后科学基金(一等资助,编号:2013M530335,2013.09–2016.09,资助金额15万)。

(5) 苝酰亚胺衍生物一维单晶纳米结构气敏传感性能的研究,河南大学优秀青年培育基金(编号:2014yqpy0084,2014.01–2018.12,资助金额27万)。

(4) 含杂原子的手性苝酰亚胺衍生物组装体气敏传感性能研究,中科院纳米系统与多级次制造重点实验室开放课题(2017.01–2017.12,资助金额 5万)。

(3) 苝酰亚胺衍生物一维单晶纳米结构气敏传感性能的研究,河南省高校青年骨干教师资助项目(编号:2013GGJS-237,2013.01–2016.12, 资助金额4万)。

(2) 苝酰亚胺衍生物单晶纳米线的制备及其气敏传感性能研究,河南省教育厅项目(编号:2011B430001,2011.1–2013.12)。

(1) 含吸电子基的苝酰亚胺衍生物单晶纳米线的制备及其气敏传感性能研究,河南大学自然基金重点项目( 编号:2010ZRZD03, 2011.1–2011,12,资助金额2万)。

二、代表性科研论文

(27) Zhonghua Liu, Xuejuan Wang, Qing Chen, Feiyan Ma, Yongwei Huang*, Yijian Gao, Qingyuan Deng, Zeng-Ying Qiao*, Xiaoyi Xing, Jianling Zhu, Feng Lu*, and Hao Wang*, Regulating Twisted Skeleton to Construct Organ-Specific Perylene for Intensive Cancer Chemotherapy, Angew. Chem. Int. Ed., 2021, 60, 16215–16233. (SCI一区, IF = 15.33, VIP 论文).

(26) Rijie Zheng, Qi Zhao, Weixia Qing, Shengliang Li, Zhonghua Liu*, Qianqian Li, and Yongwei Huang*, Carrier-Free Delivery of Ultra-small π-Conjugated Oligomer Nanoparticles with Photothermal Conversion over 80% for Cancer Theranostics, Small, 2021, DOI: 10.1002/smll.202104521. (SCI一区, IF = 13.3).

(25) Shengliang Li,† Qingyuan Deng,† Yachao Zhang,† Xiaozhen Li, Guohua Wen, Xiao Cui, Yingpeng Wan, Yongwei Huang*, Jiaxiong Chen, Zhonghua Liu, Lidai Wang*, and Chun-Sing Lee*, Rational Design of Conjugated Small Molecules for Superior Photothermal Theranostics in NIR-II Biowindow, Adv. Mater., 2020, 32, 2001146. (SCI 一区, IF = 30.8,高被引论文)

(24) Jianchen Hu , Wenfeng Kuang , Ke Deng , Wenjun Zou , Yongwei Huang*, Zhixiang  Wei*, and Charl F.J. Faul, Self-Assembled Sugar-Substituted Perylene Diimide Nanostructures with Homochirality and High Gas Sensitivity, Adv. Funct. Mater., 2012, 22, 4149–4158. (SCI一区, IF = 18.8).

(23) Shengliang Li,† Qingyuan Deng,† Xiao Li, Yongwei Huang,* Xiaozhen Li, Fang Liu, Huijuan Wang, Weixia Qing, Zhonghua Liu,* and Chun-Sing Lee*, Bis-Diketopyrrolopyrrole Conjugated Polymer Nanoparticles as Photothermic Nanoagonist for Specific and Synergistic Glioblastoma Therapy, Biomaterials, 2019, 216, 119252. (SCI一区, IF = 12.3)

(22) Yijian Gao, Qianqian Li, Chunli Li,* Leyi Gao, Huan Chen, Tingting Liu, Yongwei Huang,*

Zhonghua Liu, and Shengliang Li*, Terselenophene Regioisomer Conjugated Polymer Materials for High-Performance Cancer Phototheranostics, ACS Appl. Mater. Interfaces, 2020, 12, 55605–55613. (SCI一区, IF =9.06).

(21) Fang Liu, Feiyan Ma, Qing Chen, Enbao Zhou, Puwen Zhang, Zhanjun Cui,* Zhonghua Liu, and Yongwei Huang,* Synergistic non-bonding interactions based on diketopyrrolo-pyrrole for elevated photoacoustic imaging-guided photothermal therapy, Biomater. Sci., 2021, 9, 908–916. (SCI 二区,IF = 6.84)

(20) Zhonghua Liu, Yijian Gao, Xin Jin, Qingyuan Deng, Zengle Yin, Shuaihang Tong, Weixia Qing* and Yongwei Huang,* Regioisomer-manipulating thio-perylenediimide nanoagents for photothermal/photodynamic theranostics, J. Mater. Chem. B., 2020, 8, 5535–5544. (SCI 二区,IF = 6.33)

(19) Qingyuan Deng, Enbao Zhou, Yongwei Huang,* Weixia Qing, Haiyan Zhai, Zhonghua Liu,* and Zhixiang Wei,* Chalcogen−substitution modulated supramolecular chirality and gas sensing properties in perylenediimides, Chem. Commun., 2019, 55, 4379–4382. (SCI一区,IF = 6.0).

(18) Xuejuan Wang, Chunli Li*, Yongwei Huang*, Haiyan Zhai, Zhonghua Liu*, Dongzhu Jin, Highly sensitive and stable perylene sensor for ammonia detection: A case study of structure-property relationships, Sens. Actuators B, 2018, 275, 451–458. (SCI一区, IF = 7.1).

(17) Yongwei Huang, Shasha Zhang, Guangcai Zhong, Chunli Li*, Zhonghua Liu* and Dongzhu Jin, Highly responsive hydrazine sensors based on donor-acceptor perylene diimides: impact of electron-donating groups, Phys. Chem. Chem. Phys., 2018, 20, 19037–19044. (SCI 二区,IF = 3.4,)

(16) Shasha Zhang, Xuejuan Wang, Yongwei Huang*, Haiyan Zhai, Zhonghua Liu*, Ammonia sensing properties of perylene diimides: Effects of core-substituted chiral groups, Sens. Actuators B, 2018, 254, 805–810. (SCI一区, IF = 7.1).

(15) Yongwei Huang, Xiaotian Liu, Qing Wang, Jiya Fu*, Lili Zhao*, Zhonghua Liu* and   Dongzhu Jin, Highly responsive ethylenediamine vapor sensor based on perylenediimide–camphorsulfonic acid complex via ionic self-assembly, J. Mater. Chem. C, 2017, 5, 7644–7651. (SCI一区, IF = 7.06 ).

(14) Xiaotian Liu, Zhijian Huang, Yongwei Huang*, Lingyun Zhu* and Jiya Fu,* Tunable Supramolecular Helical Aggregate and Optoelectrical Properties of Perylene Diimides by Stereoisomerism of Sugar, J. Phys. Chem. C 2017, 121, 7558–7563. (SCI二区,IF = 4.4).

(13) Xiaotian Liu, Haiyan Zhai, Shasha Zhang, Jiya Fu* and Yongwei Huang,* Impact of alkyl chain and bay-phenoxy unit on the sensing performance of perylenediimide derivatives, Sens. Actuators B, 2017, 243, 500–506. (SCI一区, IF = 7.1).

(12) Chunli Li, Haiyan Zhai, Xiaotian Liu, Weiguang Zhang and Yongwei Huang,* Effect of stereoisomerism of alkyl chain on gas sensing properties based on perylene dyes, J. Mater. Chem. C, 2015, 3, 2778–2782. (SCI一区, IF = 7.06).

(11) Yongwei Huang,* Weiguang Zhang, Haiyan Zhai and Chunli Li,* Alkylsilane functionalized perylenediimide derivatives with differential gas sensing properties, J. Mater. Chem. C, 2015, 3, 466–472. (SCI一区,IF = 7.06).

(10) Yongwei Huang,* Junchao Wang, Haiyan Zhai, Lingyun Zhu* and Zhixiang Wei,* Helical supramolecular aggregates of sugar-based perylene deys: effect of core-substituted groups, Soft Matter, 2014, 10, 7920–7924. (SCI二区, IF = 3.4).

(9) Yongwei Huang,* Junchao Wang and Zhixiang Wei,* Modulating supramolecular helicity and electrical conductivity of perylene dyes through achiral alkyl chain, Chem. Commun., 2014, 50, 8343-4345. (SCI一区, IF = 6.0).

(8)Yongwei Huang,* Weiguang Zhang, Junchao Wang and Zhixiang Wei,* Probing the sensory property of perylenediimide derivatives in hydrazine gas: core-substituted aromatic group effect, ACS Appl. Mater. Interfaces, 2014, 6, 9307–9313. (SCI一区, IF = 8.76).

(7) Yongwei Huang*, Junchao Wang, Lina Fu, Wenfeng Kuang, Jiahua Shi*, Effect of core-substituted groups on sensing properties based on single micro/nanorod of perylenediimide derivatives, Sens. Actuators B, 2013, 188, 411–416. (SCI一区, IF = 7.1)

(6)Yongwei Huang*, Lina Fu, Wenjun Zou, Fuli Zhang, Probing the Effect of Substituted Groups on Sensory Properties Based on Single-Crystalline Micro/Nanostructures of Perylenediimide Dyes, New. J. Chem. 2012, 36. 1080–1084. (SCI三区,IF =3.1).

(5)Yongwei Huang, Ruijiang, Yuan, Shaomin Zhou*, Gas Phase-Based Growth of Highly Sensitive Single-Crystal Rectangular Micro- and Nanotubes, J . Mater. Chem. 2012, 22, 883–888. (SCI一区,IF = 6.63).

(4) Yongwei Huang*, Lina Fu, Wenjun Zou, Fuli Zhang, and Zhixiang Wei,* Ammonia Sensory roperties Based on Single-Crystalline Micro/Nanostructures of Perylenediimide Derivatives: Core-Substituted Effect, J. Phys. Chem. C 2011, 115, 10399–10404. (SCI二区,IF = 4.4).

(3) Yongwei Huang, Jianchen Hu, Wenfeng Kuang, Zhixiang Wei* and Charl F. J. Faul,

Modulating helicity through amphiphilicity—tuning supramolecular interactions for the controlled

assembly of perylenes”, Chem. Commun., 2011, 47, 5554–5556. (SCI一区,IF = 6.0).

(2) Yongwei Huang, Yong Yan, Bernd M. Smarsly, Zhixiang Wei* and Charl FJ Faul,* Helical Supramolecular Aggregates, Liquid Crystallinity and Nanofibers of a Perylenebisimide - Chiral Surfactant Complex via Ionic Self-Assembly” J .Mater. Chem. 2009, 19, 2356–2362. (SCI一区, IF = 6.6).

(1) Yongwei Huang, Baogang Quan, Zhixiang Wei*, Guangtong Liu, Lianfeng Sun, Self-Assembled Organic Functional Nanotubes and Nanorods and Their Sensory Properties, J. Phys. Chem. C, 2009, 113, 3929–3933. (SCI二区,IF = 4.4).

三、发明专利

(1)一种苝酰亚胺衍生物微米或纳米线及其应用,国家发明专利,中国,2015, 2, 25授权,黄永伟, 林波, 张磊, 付丽娜, 刘笑天,专利号:ZL2013100782790。

(2) 一种苝酰亚胺衍生物微米线及其应用,国家发明专利,中国,2015, 2, 25授权,黄永伟, 李春丽, 李慧, 付丽娜, 翟海燕,专利号:ZL2013100860573。

(3) 一种含α-吡喃糖苷的苝酰亚胺衍生物及其制备方法和应用,国家发明专利,中国,2018, 11, 16授权,黄永伟,刘中华,厉永强,刘笑天,王学娟,专利号:ZL2016109479326。

(4) 一种含有S-构型樟脑磺酸的苝酰亚胺衍生物及其制备方法、应用,国家发明专利,中国,2019, 04, 09授权,黄永伟,张磊,刘中华,王学娟,张沙沙,专利号:ZL201710408408.6。

(5) 一种含β-吡喃糖苷的苝酰亚胺衍生物及其制备方法和应用,国家发明专利,中国,2019, 05, 31授权,黄永伟,李春丽,汤昆,张卫光,黄志坚, 专利号:ZL201610968249.0。

(6) 一种苝湾1,7-位含有硝基的苝酰亚胺衍生物及其在氨气检测中的应用,国家发明专利,中国,2019, 05, 31授权,黄永伟,李春丽,张卫光,邓青源,张沙沙,专利号:ZL201710423929.9。

(7) 一种细胞膜成像荧光探针及其应用,国家发明专利,中国,2020, 12, 11授权,黄永伟,刘中华,刘芳,李晓,王俊超,专利号:ZL201810273391.2。

(8) 一种苝酰亚胺衍生物及应用,国家发明专利,中国,2021, 10, 20授权,黄永伟,刘中华,王颖哲,马翡雁,高一剑,专利号:ZL 202011603976.X。

四、获奖

(1) 苝酰亚胺衍生物纳米材料制备和性能,2018,河南省科技进步(自然科学)叁等奖,第一获奖人。

(2) 苝酰亚胺衍生物纳米材料制备和性能,2018,河南省教育厅科技进步壹等奖,第一获奖人。

(3) Ammonia Sensory Properties Based on Single-Crystalline Micro/Nanostructures of

Perylenediimide Derivatives: Core-substituted Effect,2013,河南省第二届自然科学优秀学

术论文壹等奖,第一获奖人;

(4) Modulating supramolecular helicity and electrical conductivity of perylene dyes through achiral alkyl chain,2015,河南省第三届自然科学优秀学术论文壹等奖,第一获奖人。