孙华，女，1987年生，讲师。

受教育经历

2013/09-2016/06，暨南大学，药学院中药化学专业，博士

2010/09-2013/06，暨南大学，药学院药物化学专业，硕士

工作经历

2016.07-至今，河南大学药学院，从事教学科研工作。

研究兴趣

主要从事药物代谢动力学及肿瘤药理学研究。

近5年主持或参加科研项目（课题）：

（1）国家自然科学基金青年基金，81703801，外排转运体影响中药酚性物质磺酸化代谢及作用机制研究，2018.1-2020.12，20万元，在研，主持。

（2）中国博士后科学基金面上资助二等资助，2018M632764，硫酸酯酶调控中药酚性物质外排-代谢相互作用机制研究，5万元，在研，主持。

（3）国家自然科学基金面上项目，81772832，基于EGFR介导的β-catenin浆核穿梭研究AKT1对乳腺癌转移的负性调控，2018.1-2021.12，53万元，在研，参与。

（4）国家自然科学基金青年基金，81701110，Wnt5b介导P2X3受体上膜的机制及其在骨癌痛中的作用研究，2018.1-2020.12，20万元，在研，参加。

近5年发表代表性论文

[1] Sun Hua#，Liu Hui#，Zhao Huinan，Wang Ying，Li Yaolan，Ye Wencai*，Wu Baojian*，Pharmacokinetic characterization of anhuienoside C and its deglycosylated metabolites in rats. Xenobiotica. 2017; 47(10):885-893.

[2] Sun Hua#, Zhou Xiaotong#, Zhang Xingwang, Wu Baojian*. Decreased Expression of Multidrug Resistance-Associated Protein 4 (MRP4/ABCC4) Leads to Reduced Glucuronidation of Flavonoids in UGT1A1-Overexpressing HeLa Cells: The Role of Futile Recycling. J Agric Food Chem. 2015; 63(26):6001-6008.

[3] Sun Hua#, Wang Xiao#, Zhou Xiaotong, Lu Danyi, Ma Zhiguo, Wu Baojian*. Multidrug Resistance-Associated Protein 4 (MRP4/ABCC4) Controls Efflux Transport of Hesperetin Sulfates in Sulfotransferase 1A3-Overexpressing Human Embryonic Kidney 293 Cells. Drug Metab Dispos. 2015; 43(10):1430-1440.

[4] Li Wan#, Sun Hua#, Zhang Xingwang, Wang Huan, Wu baojian*. Efflux transport of chrysin and apigenin sulfates in HEK293 cells overexpressing SULT1A3: The role of multidrug resistance-associated protein 4 (MRP4/ABCC4). Biochem Pharmacol. 2015; 98(1):203-214.

[5] Sun Hua#, Ma Zhiguo#, Lu Danyi, Wu Baojian*. Regio- and Isoform-Specific Glucuronidation of Psoralidin: Evaluation of 3-O-Glucuronidation as a Functional Marker for UGT1A9. J Pharm Sci. 2015; 104(7):2369-2377.

[6] Sun Hua#, Zhou Xiaotong#, Wu Baojian*. Accurate identification of UDP-glucuronosyltransferase 1A1 (UGT1A1) inhibitors using UGT1A1-overexpressing HeLa cells. Xenobiotica. 2015; 45(11):945-953.

[7] Sun Hua#, Wang Huan#, Liu Hongming, Zhang Xingwang, Wu Baojian*. Glucuronidation of capsaicin by liver microsomes and expressed UGT enzymes: reaction kinetics, contribution of individual enzymes and marked species differences. Expert Opin Drug Metab Toxicol. 2014; 10(10):1325-1336.

[8] Sun Hua, Zhang Tianpeng, Wu Zhufeng, Wu Baojian*. Warfarin is an Effective Modifier of Multiple UDP-Glucuronosyltransferase Enzymes: Evaluation of its Potential to Alter the Pharmacokinetics of Zidovudine. J Pharm Sci. 2014; 104(1):244-256.

[9] Liu Hongming#, Sun Hua#, Wu Zhufeng, Zhang Xingwang, Wu Baojian*. P-glycoprotein (P-gp)-mediated efflux limits intestinal absorption of the Hsp90 inhibitor SNX-2112 in rats. Xenobiotica. 2014; 44(8):763-768