Doctor of Medicine, master’s supervisor, and returned overseas scholar. To date, he has published 18 SCI-indexed academic papers as the first (co-first) or corresponding author, and authored 1 scholarly monograph. He has hosted 1 National Natural Science Foundation, 4 provincial-level science foundations, and 2 departmental-level science foundations. As a major participant, he has been involved in 3 National Natural Science Foundations. As a major inventor, he has been authorized 4 national invention patents and has received 4 academic awards. For a long time, he has taught “Introduction to Medicine” and “Medical English” to undergraduate students majoring in Clinical Medicine, and “Medical English” to master’s students majoring in Basic Medicine. Under his guidance, more than 10 master’s students majoring in Pathology and Pathophysiology have successfully graduated.
1. Key Program for Science and Technology of Henan Province, China (2024.1~2025.12). The effect and mechanism of Wnt4-mediated canonical Wnt signaling on the pathogenesis of non-small cell lung cancer. (Principal Investigator)
2. Henan Provincial Natural Science Foundation, China (2023.1~2024.12). The effect and mechanism of Wnt/mitochondria axis on the pathogenesis of diabetic peripheral neuropathy. (Principal Investigator)
3. Co-Construction Medical Program for Science and Technology of Henan Province, China (2022.1~2024.12). The effect of LRP5 on the progression of cervical cancer. (Principal Investigator)
4. Henan Provincial Medical Education Research Project, China (2021.1~2022.12). The Application of "Clinical conversation-oriented" teaching mode in medical English teaching. (Principal Investigator)
5. Key Program for Science and Technology of Henan Province, China (2020.1~2021.12). The role of LRP5 in the pathogenesis colorectal cancer. (Principal Investigator)
6. National Natural Science Foundation of China (2020.1~2023.12). The effect and mechanism of FXR/miR-149-3p signaling pathway on the pathogenesis of type 2 diabetes mellitus. (The First Participant)
7. National Natural Science Foundation of China (2018.1~2020.12). The effect and mechanism of miR-152-3p/mitochondria pathway on the pathogenesis of type 2 diabetes mellitus. (Principal Investigator)
8. Henan Provincial Natural Science Foundation, China (2017.1~2018.12). The effect and mechanism of miR-152-3p on the dysfunction of pancreatic β cell during diabetes mellitus. (Principal Investigator)
9. National Natural Science Foundation of China (2015.1~2018.12). The role and effect of bile acid nuclear receptor FXR on the pathogenesis of liver cancer. (The First Participant)
1. Crosstalk between WNT signaling and ferroptosis in cancer. Mol Cancer Res. 2024 Dec 30. Corresponding author
2. Combination therapies with Wnt signaling inhibition: A better choice for prostate cancer treatment. Biochim Biophys Acta Rev Cancer. 2024 Sep 25;1879(6):189186. Corresponding author
3. Emerging diabetes therapies: Regenerating pancreatic β cells. Tissue Eng Part B Rev. 2024 Sep 27. Corresponding author
4. Wnt signaling: Modulating tumor-associated macrophages and related immunotherapeutic insights. Biochem Pharmacol. 2024 May:223:116154. Corresponding author
5. WNT Ligands in Non-Small Cell Lung Cancer: From Pathogenesis to Clinical Practice. Discov Oncol. 2023 Jul 24;14(1):136. Corresponding author
6. LRP5 promotes gastric cancer via activating canonical Wnt/β-catenin and glycolysis pathways. Am J Pathol. 2022 Mar;192(3):503-517. First author
7. LRP5 promotes cancer stem cell traits and chemoresistance in colorectal cancer. J Cell Mol Med. 2022 Feb;26(4):1095-1112. First author
8. miRNA-382-5p Suppresses the Expression of Farnesoid X Receptor to Promote Progression of Liver Cancer. Cancer Manag Res. 2021 Oct 22;13:8025-8035. First author
9. The complex role of Wnt ligands in type 2 diabetes mellitus and related complications. J Cell Mol Med. 2021 Jul;25(14):6479-6495. First author
10. Emerging roles of Wnt ligands in human colorectal cancer. Front Oncol. 2020 Aug 14;10:1341. First author
11. Downregulation of Wnt3 Suppresses Colorectal Cancer Development Through Inhibiting Cell Proliferation and Migration. Front Pharmacol. 2019 Oct 1;10:1110. First author
12. “Heterogeneity of Head and Neck Squamous Cell Carcinoma Stem Cells” in the book of “Stem Cells Heterogeneity in Cancer”, Springer, Adv Exp Med Biol. 2019; 1139:23-40. (Book Chapter)
13. Interplay of miRNAs and Canonical Wnt Signaling Pathway in Hepatocellular Carcinoma. Front Pharmacol. 2018 Jun 21;9:657. First author
14. Reactive oxygen species in cancer stem cells of head and neck squamous cancer. Semin Cancer Biol. 2018 Dec;53:248-257. Co-first author
15. Quercetin inhibits LPS-induced inflammation and ox-LDL-induced lipid deposition. Front Pharmacol. 2017 Feb 3;8:40. Co-first author
16. Down-regulating overexpressed human Lon in cervical cancer suppresses cell proliferation and bioenergetics. PLoS One, 2013, 8(11): e81084. First author
17. Phosphorylation of human TFAM in mitochondria impairs DNA binding and promotes degradation by the AAA+ Lon protease. Mol Cell, 2013 Jan 10;49(1):121-132. Co-first author
1. The application of a biomarker for the diagnosis and treatment of gastrointestinal carcinomas. Feb. 5, 2021, China, No: ZL201910524293.6. The second inventor
2. The application of a miRNA biomarker hsa-miR-149-3p for the diagnosis of type 2 diabetes mellitus. Mar. 5, 2019, China, No: ZL201610655996.9. The second inventor
3. A biomarker for the diagnosis of digestive system carcinomas and related preparation method. Feb. 5, 2021, China, No: ZL201910318890.3. The second inventor
4. The application of LRP5 in the diagnosis and treatment of digestive system carcinomas. Jan. 22, 2021, China, No: ZL201710124101.3. The third inventor
1. Excellent Scientific Paper Award given by Education Department of Henan province, 2023. (The first author, First Prize)
2. Excellent Scientific Paper Award given by Education Department of Henan province, 2022. (The first author, Second Prize)
3. Science and Technology Award given by Education Department of Henan province, 2021. (The third winner, First Prize)
4. Excellent Scientific Paper Award given by Education Department of Henan province, 2021. (The first author, First Prize)
5. The 13th Youth Science and Technology Prize of Kaifeng City, 2019.
