Chai Lihui-河南大学医学院官方网站

Lihui Chai, Ph.D., Professor.

He graduated from Henan Medical University (now Medical School of Zhengzhou University) with a bachelor's degree in clinical medicine in 2000, and received a Ph.D. in immunology from the School of Basic Medical Sciences, Zhengzhou University in 2013. He served as a visiting scholar at the Perelman School of Medicine, University of Pennsylvania, USA (November 2011 to November 2012) and the University of Nebraska Medical Center, USA (December 2015 to March 2016).

He has served as an assistant lecturer, lecturer, and associate professor in the Immunology Department, School of Medicine, Henan University. He is currently the Vice dean of the School of Basic Medical Sciences, Henan University, and the Deputy Secretary-General of the Henan Immunological Society.

His main research areas focus on innate immunity and tumor immunity. He has led and participated in six national natural science foundation projects, and published over 30 academic papers in journals such as the Journal of Immunology and Frontiers in Immunology. He has received the Second Prize for Medical Science and Technology Progress in Henan Province, the First Prize for Teaching Achievements in Higher Education in Henan Province (twice), and the Second Prize for Teaching Achievements in Higher Education in Henan Province. He has also been granted three authorized national invention patents.

1.National Natural Science Foundation of China, General Project, 81971497, "Regulatory Role and Mechanism of Tnfaip8 in Innate Immune Responses Triggered by TLR and RIG-I Receptors," January 2020 - December 2023, 580,000 RMB, in progress, participant.

2.Henan Province Natural Science Foundation, General Project, 212300410329, "Molecular Mechanism of TNFAIP8 in Regulating Proliferation, Metastasis, and Cisplatin Resistance in Cervical Cancer Cells," January 2021 - December 2022, 100,000 RMB, in progress, principal investigator.

3.National Natural Science Foundation of China, Joint Project, U1504309, "Molecular Mechanism of OCILRP2, a C-Type Lectin-Associated Protein, in Promoting DC Maturation by Modulating TLR4 Signaling," January 2016 - December 2018, 300,000 RMB, completed, principal investigator.

4.Key Scientific Research Project of Henan Province Higher Education Institutions, 15A310015, "Molecular Mechanism of OCILRP2 Receptor Signals in Regulating DC Maturation and Activation," January 2015 - December 2016, 20,000 RMB, completed, principal investigator.

1. Mingya Cao, Lina Ma, Chenyang Yan, Han Wang, Mengzhe Ran, Ying Chen, Xiao Wang, Xiaonan Liang, Lihui Chai, Xia Li; Mouse Ocilrp2/Clec2i negatively regulates LPS-mediated IL-6 production by blocking Dap12-Syk interaction in macrophage. Frontiers in immunology 2022;13:984520 doi:10.3389/fimmu.2022.984520

2. Jingyi Peng, Jiaguo Wu, Ning Shi, Hua Xu, Longlong Luo, Jing Wang, Xinying Li, He Xiao, Jiannan Feng, Xia Li, Lihui Chai, Chunxia Qiao; A Novel Humanized Anti-Abrin A Chain Antibody Inhibits Abrin Toxicity In Vitro and In Vivo. Frontiers in immunology 2022;13:831536 doi:10.3389/fimmu.2022.831536

3. Yaohui Wang, Hailong Zhang, Zhizeng Wang, Yinxiang Wei, Mingli Wang, Meichen Liu, Xuance Wang, Yinan Jiang, Gongning Shi, Dongmei Zhao, Zhengyan Yang, Zhiguang Ren, Jing Li, Zhenkai Zhang, Zhenfeng Wang, Bei Zhang, Beibei Zong, Xueke Lou, Chengguo Liu, Zihui Wang, Hao Zhang, Ningya Tao, Xuefang Li, Xingkun Zhang, Yafei Guo, Yang Ye, Yu Qi, Hui Li, Man Wang, Rongxin Guo, Guanchang Cheng, Shulian Li, Jun Zhang, Guangchao Liu, Lihui Chai, Qiang Lou, Xia Li, Xiukun Cui, Erhe Gao, Zheng Dong, Yanzhong Hu, Youhai H Chen, Yuanfang Ma; Blocking the death checkpoint protein TRAIL improves cardiac function after myocardial infarction in monkeys, pigs, and rats.Science translational medicine 2020 04 22;12(540) doi:10.1126/scitranslmed.aaw3172

4. Suxia Wu, Weihua Li, Zhenghui Wu, Tianran Cheng, Ping Wang, Na Li, Xiaonan Liang, Mengmeng Chi, Shuman Zhang, Yuanfang Ma, Yanyun Li, Lihui Chai; TNFAIP8 promotes cisplatin resistance in cervical carcinoma cells by inhibiting cellular apoptosis.Oncology letters 2019 May;17(5):4667-4674 doi:10.3892/ol.2019.10076

5. Lihui Chai, Suxia Wu, Guangchao Liu, Zhanzheng Wang, Wenzhi Tian, Yuanfang Ma; OCILRP2 signaling synergizes with LPS to induce the maturation and differentiation of murine dendritic cells.Biochemical and biophysical research communications 2014 Apr 18;446(4):836-42 doi:10.1016/j.bbrc.2014.02.145

6. Honghong Sun, Guohong Zhuang, Lihui Chai, Zhaojun Wang, Derek Johnson, Yuanfang Ma, Youhai H Chen; TIPE2 controls innate immunity to RNA by targeting the phosphatidylinositol 3-kinase-Rac pathway.Journal of immunology (Baltimore, Md. : 1950) 2012 Sep 15;189(6):2768-73 doi:10.4049/jimmunol.1103477

1.Chai Lihui, Ma Yuanyang, Wu Suxia, Zhang Sannv, Yang Fei, Li Weihua, Feng Shiming, Dong Guoqing, Liu Guangchao. Method for silencing the TNFAIP8 gene and its application in tumor therapy. October 30, 2018, China, ZL201510830193.8

2.Ma Yuanyang, Liu Fengtao, Chai Lihui, Zhang Jun, Liu Guangchao, Li Shulian. Novel polyvalent antibodies targeting death receptors and their application in preparing anti-tumor drugs. May 17, 2019, China, ZL201310725221.0

3.Wang Zhizeng, Ma Yuanyang, Jing Jing, Guo Yafei, Tao Ningya, Zhang Bei, Liu Guangchao, Li Shulian, Zhang Jun, Chai Lihui. Colloidal selenium, colloidal selenium-based markers, detection cards, their preparation methods, and their application in detecting clenbuterol hydrochloride. January 15, 2019, China, ZL 201710343657.1

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