Wang Yaohui-河南大学医学院官方网站

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Wang Yaohui Professor

Email: wangyaohui2017@henu.edu.cn

Research Fields:

Cardiovascular immunity; Novel biomedicine research and development

Biography
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Authorized Patent

Yaohui Wang, Ph.D., Professor, doctoral supervisor, Deputy Dean of School of Basic Medical Sciences, Henan University. He graduated from the School of Medicine of Henan University with a Bachelor's degree in Medicine in 2006 and from Shanghai Medical College of Fudan University with a Doctor's degree in pathogen biology in 2011. 2014 Visiting Scholar of Yang Luling School of Medicine, National University of Singapore. The main research areas include innovative antibody drug development, mechanisms of myocardial damage after myocardial infarction, and cardiac protection. Scientific and technological innovation talents in universities of Henan Province, hosted 4 National Natural Science funds, and Henan Outstanding Youth Science Funds; Published a series of research papers in Sci Transl Med, J. Biol.Chem.; 5 invention patents were approved and 1 was transformed.

1. Mechanism and targeted intervention of myocardial damage/repair mediated by natural immune cells after myocardial infarction, January 2024.01-2026.12, 500,000 yuan, Outstanding Youth Project of Henan Natural Science Foundation.

2. Study on the mechanism of microvascular endothelial cell derived MYDGF regulating CD248 to protect myocardium after myocardial infarction, January 2024.01-2027.12, 490,000 yuan, National Natural Science Foundation of China Project.

3. Research on the establishment and mechanism of cardiac targeted drug delivery System after myocardial Infarction based on Death receptor 5, 2022.01-2024.12, 300,000 yuan, Scientific and Technological Innovation Talents of Henan Universities.

4. Study on the mechanism of GDF11 inhibition of mtDNA damage - inflammatory response axis to improve myocardial injury after myocardial infarction, 2021.01-2024.12, 550,000 yuan, National Natural Science Foundation of China.

5. Study on the mechanism of TIPE2-mediated DNA damage promoting hepatocyte malignant transformation induced by hepatitis C virus, 2015.01-2017. 12, 230,000 yuan, National Natural Science Foundation of China.

6. Mechanism of human soluble DR5 protein alleviating myocardial ischemia-reperfusion injury by blocking TRAIL, 2015.01-2017.12, 300,000 yuan, National Natural Science Foundation of China - Henan.

7. The regulatory mechanism of cardiac resident macrophages on ventricular remodeling after myocardial infarction, 2020.10-2023.09, 250,000 yuan, Henan Provincial Outstanding Youth Science Foundation.

1. Xuance Wang^#, Ran Xie^#, Dan Zhao, Guiling Wang, Lijie Zhang, Wei Shi, Yanyan Chen, Tingting Mo, Yuxin Du, Xuefei Tian, Wanjun Wang, Run Cao, Yuanfang Ma, Yinxiang Wei*, Yaohui Wang* Blocking the TRAIL-DR5 Pathway Reduces Cardiac Ischemia-Reperfusion Injury by Decreasing Neutrophil Infiltration and Neutrophil Extracellular Traps Formation. Cardiovasc Drugs Ther. 2024 Jun 20.

2. Lijie Zhang^#, Xingkun Zhang^#, Xiaoming Zhong^#, Mengya Fan, Guoliang Wang, Wei Shi, Ran Xie, Yinxiang Wei, Hailong Zhang, Xiangxu Meng, Yaohui Wang*, Yuanfang Ma* Soluble Flt-1 in AMI Patients Serum Inhibits Angiogenesis of Endothelial Progenitor Cells by Suppressing Akt and Erk’s Activity. Biology (Basel). 2022 Aug 9;11(8):1194.

3. Chunxia Chen^#, Hao Zhang ^#, Ran Xie, Yaohui Wang^*, Yuanfang Ma^* Gut microbiota aggravate cardiac ischemia-reperfusion injury via regulating the formation of neutrophils extracellular traps. Life Sci. 2022 Aug 15;303:120670.

4. Zhizeng Wang ^#, Qianwen Zhou^#, Yafei Guo^#, Hangzhan Hu, Zhi Zheng, Shulian Li, Yaohui Wang*, Yuanfang Ma^* Rapid Detection of Ractopamine and Salbutamol in Swine Urine by Immunochromatography Based on Selenium Nanoparticles. Int J Nanomedicine. 2021 Mar 9;16:2059-2070.

5. Yaohui Wang^#, Hailong Zhang^#, Zhizeng Wang^#, Yinxiang Wei^#, Mingli Wang, Meichen Liu, Xuance Wang, Yinan Jiang, Gongning Shi, Dongmei Zhao, Zhengyan Yang, Zhiguang Ren, Jing Li, Zhenkai Zhang, Zhenfeng Wang, Bei Zhang, Beibei Zong, Xueke Lou, Chengguo Liu, Zihui Wang, Hao Zhang, Ningya Tao, Xuefang Li, Xingkun Zhang, Yafei Guo, Yang Ye, Yu Qi, Hui Li, Man Wang, Rongxin Guo, Guanchang Cheng, Shulian Li, Jun Zhang, Guangchao Liu, Lihui Chai, Qiang Lou, Xia Li, Xiukun Cui, Erhe Gao, Zheng Dong, Yanzhong Hu, Youhai H. Chen^*, and Yuanfang Ma^*Blocking the death checkpoint protein TRAIL improves cardiac function after myocardial infarction in monkeys, pigs, and rats. Sci Transl Med., 2020 Apr 22;12(540).

6. Zhizeng Wang^#, Zhi Zheng^#, Hangzhan Hu^#, Qianwen Zhou, Wei Liu, Xiaoquan Li, Zhigang Liu, Yaohui Wang*, Yuanfang Ma* A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood. Lab Chip. 2020 Nov 10;20(22):4255-4261.

Hailong Zhang^#, Yuting Ma^#, Run Cao^#, Guanli Wang, Shaowei Li, Yue Cao, Hao Zhang, Meichen Liu, Guangchao Liu, Jun Zhang, Shulian Li, Yaohui Wang*, Yuanfang Ma* Soluble uric acid induces myocardial damage through activating the NLRP3 inflammasome. J Cell Mol Med. 2020 Aug;24(15):8849-8861.

1. Ma Yuanfang, Wang Yaohui et al sDR5-Fc fusion protein mutant and its application (ZL201510510981.9).

2. Ma Yuanfang, Wang Yaohui et al. Application of GDF11-Fc fusion protein in the treatment of ulcerative colitis, Patent No. ZL201810008965.3.

3. Wang Yaohui, Wei Yinxiang et al., A multi-axis crush simulator, patent number: ZL202210197082.8.

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