Ruan Qingguo-河南大学医学院官方网站

Dr.Ruan received his Ph.D. from University of Florida in 2004. From 2004 to 2013, he finished his postdoctoral training and worked as a Research Associate at University of Pennsylvania. From 2013 to 2018, he was a professor at Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences. From 2019 to 2023, he worked as a professor at Shandong Eye Institute, Shandong First Medical University. Since 2024, he has been a Distinguished Professor at National and Local Joint Laboratory of Antibody Drug Engineering, Henan University. He was honored as “Distinguished Researcher” (2016) and "One Hundred Talents” (2014) of Chinese Academy of Sciences, “High-Level Talents” of Shandong Province (2019) and Shenzhen (2013). With over 30 years of research experience in the field of immunology, he has published over 60 SCI papers in journals such as Science, Immunity, Nat Immunol, Nat Commun, J Exp Med, PNAS, and Diabetes. He has been granted one US patent and two domestic invention patents, and has been project leader of multiple scientific research projects including three general projects from National Natural Science Foundation of China (NSFC). He has frequently given talks at international academic conferences and served as a council member of the Immunology Society of Guangdong Province and as a reviewer for major projects of the Ministry of Science and Technology and NSFC projects. He has won the 2^nd prize of National Science and Technology Progress award in 2015 (ranked 4^th) and 1995 (ranked 9^th), 1^stprize of Shandong Provincial Technology Invention award in 2022 (ranked 7^th), 2^nd prize of Shandong Provincial Science and Technology Progress award in 2024 (ranked 2^nd), and the NIH Junior Faculty award in 2009.

1. General Research Program of National Natural Science Foundation of China (Project leader), 82471063, 700,000 (RMB), 2025-2028

2. General Research Program of National Natural Science Foundation of China (Project leader), 82271129, 520,000 (RMB), 2023-2026

3. Key Research Program of National Natural Science Foundation of China (Sub-project leader), 81530027, 2,500,000 (RMB), 2015-2019

4. General Research Program of National Natural Science Foundation of China (Project leader), 81471554, 710,000 (RMB), 2014-2018

5. 100 Talents Program (Project leader), Chinese Academy of Sciences, 1000,000 (RMB), 2014-2017

6. Shenzhen Key Research Program (Project leader), JCYJ20170413165432016, 2,000,000 (RMB), 2017-2020

7. Shenzhen Peacock Technology Innovation Program (project leader)，KQJSCX20160301140901，1,000,000 (RMB), 2016-2018

8. Shenzhen Basic Research Program (Project leader), JCYJ20140610151856705, 300,000 (RMB), 2014-2016

9. Shenzhen Basic Research Program (Project leader), JCYJ20130401170412298, 150,000 (RMB), 2013-2015

10. Shenzhen Basic Research Program (Project leader), JCYJ20160531185449995, 300,000 (RMB), 2016-2018

11. Qingdao Basic Research Program (Project leader)，21-1-4-rkjk-11-nsh, 500,000 (RMB)，2021-2022

12. Guangdong Provincial Basic Research Program (Project leader), B2013B021800165, 50,000 (RMB), 2013-2016

1. Liu R, Liu C, He X, Sun P, Zhang B, Yang H, Shi W, Ruan Q*. MicroRNA-21 promotes pancreatic β cell function through modulating glucose uptake. Nat Commun，2022, 13(1):3545.

2. Ruan Q, Kameswaran V, Tone Y, Li L, Liou HC, Greene MI, Tone M, Chen YH. Development of Foxp3(+) regulatory t cells is driven by the c-Rel enhanceosome. Immunity. 2009, 31(6):932-40,

3. Ruan Q, Kameswaran V, Zhang Y, Zheng S, Sun J, Wang J, Devirgiliis J, Liou HC, Beg AA, Chen YH. The Th17 Immune Response Is Controlled By A c-Rel-ROR-RORrT Transcriptional Axis. J Exp Med. 2011, 208(11): 2321-33.

4. Ruan Q, Wang T, Kameswaran V, Wei Q, Johnson DS, Matschinsky F, Shi W, Chen YH. The microRNA-21−PDCD4 axis prevents type 1 diabetes by blocking pancreatic β cell death. PNAS. 2011; 108(29):12030-5.

5. Ruan Q, Zheng SJ, Palmer S, Carmody RJ, Chen YH. Roles of Bcl-3 in the Pathogenesis of Murine Type 1 Diabetes. Diabetes. 2010, 59(10):2549-57.

6. Ruan Q, Wang P, Wang T, Qi J, Wei M, Wang SW, Fan TT, Johnson DS, Wan XC, Shi WY, Sun HH, Chen YH*. MicroRNA-21 Regulates T Cell Apoptosis by Directly Targeting the Tumor Suppressor Gene Tipe2. Cell Death & Disease, 2014, 5: e1095.

7. Bian J, Wang T, Sun J, He X, Wu Z, Zhang S, Chi H, Fan T, Wang S, Shi W, Ruan Q*. Targeting NF-κB c-Rel in regulatory T cells to treat corneal transplantation rejection. Am J Transplant. 2021, 21(12):3858-3870.

8. Ruan QG, Wang CY, Shi JD, She JX. Expression and Alternative Splicing of the Mouse Autoimmune Regulator Gene (Aire). J Autoimmun. 1999, 13:307.

9. He X, Liu R, Fan T, Huang X, Wu C, Su W, Wang T, Ruan Q*. Treating Autoimmune Diseases by Targeting IL-23 with Gene-Silencing Pyrrole-Imidazole Polyamide. J Immunol. 2020, 204(8):2053-2063.

10. Bian J, Liu R, Fan T, Liao L, Wang S, Geng W, Wang T, Shi W, Ruan Q*. miR-340 Alleviates Psoriasis in Mice through Direct Targeting of IL-17A. J Immunol. 2018; 201(5):1412-1420.

11. Ruan QG, Tung K, Eisenman D, Setiady Y, Eckenrode S, Yi B, Purohit S, Zheng WP, Zhang Y, Peltonen L, She JX. The autoimmune regulator directly controls the expression of genes critical for thymic epithelial function. J Immunol. 2007, 178(11):7173-7180.

12. Zheng Q, Liu R, Jiang B, Sun J, Wang T, Ruan Q*. NF-κB c-Rel Is a Potential Therapeutic Target for Acute Corneal Transplant Rejection. Invest Ophthalmol Vis Sci. 2023; 64(14):16.

13. Sun J, Wang T, Bian J, Shi W, Ruan Q*. Immune tolerance induced in the anterior chamber ameliorates corneal transplant rejection. Clin Immunol. 2023, 257:109797.

14. Fan T, Wang S, Yu L, Yi H, Liu R, Geng W, Wan X, Ma Y, Cai L, Chen YH, Ruan Q*, Treating psoriasis by targeting its susceptibility gene Rel，Clin Immunol. 2016; 165:47-54.

15. Zhao W, He X, Liu R, Ruan Q*. Accelerating corneal wound healing using exosome-mediated targeting of NF-κB c-Rel. Inflamm Regen. 2023; 43(1):6.

16. Sun J, Liu R, He X, Bian J, Zhao W, Shi W, Ruan Q*. MicroRNA-21 Regulates Diametrically Opposed Biological Functions of Regulatory T Cells. Front Immunol. 2021, 12:766757.

17. Bian J, Wang K, Wang Q, Wang P, Wang T, Shi W, Ruan Q*. Dracocephalum heterophyllum (DH) Exhibits Potent Anti-Proliferative Effects on Autoreactive CD4+ T cells and Ameliorates the Development of Experimental Autoimmune Uveitis. Front Immunol. 2020, 11:1-18.

18. Liu R, He X, Geng W, Wang T, Ruan Q*. Loss of TIPE2 Has Opposing Effects on the Pathogenesis of Autoimmune Diseases. Front Immunol. 2019; 10: 2284.

19. Carmody RJ, Ruan Q, Palmer S, Hilliard B, Chen YH. Negative Regulation of Toll-Like Receptor Signaling by NF-kB p50 Ubiquitination Blockade. Science. 2007, 317(5838):675-678.

1. C-REL-SPECIFIC SIRNA AND ITS USE FOR PREVENTING AND TREATING AUTOIMMUNE PSORIASIS, USA，US 10,081,810 B2, 2018.9.

2. C-REL-SPECIFIC SIRNA AND ITS USE FOR PREVENTING AND TREATING AUTOIMMUNE PSORIASIS，China，ZL 2015 8 0001128.2, 2021.3.

3. Application of Pentoxifylline in Corneal Transplantation Rejection，China，ZL 2022 1 1555478.1, 2024.11.

1. 2^nd prize of National Science and Technology Progress award (ranked 4^th)，2015

2. 2^nd prize of National Science and Technology Progress award (ranked 9^th)，1999

3. 2^nd prize of Shandong Provincial Science and Technology Progress award (ranked 2^nd)，2025

4. 1^st prize of Shandong Provincial Technology Invention award (ranked 7^th)，2022

Teachers

Outstanding Talents

Ruan Qingguo Professor

Address

Phone

Postcode

Email