河南大学医学院官方网站

郭向前

博士、教授、黄河学者
郭向前

一、个人简介:

郭向前,博士,河南大学基础医学院教授、黄河学者、杰出人才特区支持计划第四层次特聘教授,医学生物信息学研究所所长,河南省高校科技创新人才。担任中国老年医学学会基础与转化医学分会青年委员、河南省抗癌协会肿瘤精准医学专业委员会常务委员。近几年,发表SCI论文26篇,论文被引用1000多次,论文期刊总影响因子231。

二、主要研究方向:

主要从事肿瘤分子分型、肿瘤基因标记物筛选、肿瘤基因靶向性治疗、分子遗传学、生物信息学等研究。

三、承担的研究项目:

1.中国人群平滑肌肉瘤分子分型及靶向性治疗手段研究,国家自然科学基金青年项目,81602362,2017-2020,18万,主持。

2.中国人群平滑肌肉瘤分子亚型及靶向性治疗手段探索,河南省科技攻关计划,162102310391,2015-2017,10万,主持。

3.食管腺癌精准医疗,河南省青年骨干教师培养计划,2016GGJS-214,2017-2019,主持。

4.中原地区食管腺癌分子分型及亚型诊断标记物的开发,河南省高校科技创新人才,18HASTIT048,60万,2018-2019,主持。

5.黄河学者基金,H2016012,河南大学,50万,2016-2020,主持。

6.杰出人才特区支持计划第四层次基金,河南大学,200万,2017-2022,主持。

7.优青培育基金,yqpy20170039,河南大学,10万,2017-2019,主持。

8.国家自然科学基金培育基金,2015YBZR048,河南大学,1.2万,2015-2017,主持。

9.新非编码RNA及其基因的系统发现和“双色网络”构建,国家重点基础研究发展计划(973计划),2009CB825401,486万,2009-2013。参与。

四、已发表论文:

1. An Y, Wang S, Li S, Zhang L, Wang D, Wang H, Zhu S, Zhu W, Li Y, Chen W, Ji S, Guo X. Distinct molecular subtypes of uterine leiomyosarcoma respond differently to chemotherapy treatment. BMC Cancer. 2017 Sep 11;17(1):639. doi: 10.1186/s12885-017-3568-y. (Corresponding Author) (IF= 3.288, SCI二区)

2. Fang, N., T. Gu, Y. Wang, S. Wang, F. Wang, Y. An, W. Wei, W. Zhang, X. Guo, A. Nazarali, S. Ji. Expression of PTEN-long mediated by CRISPR/Cas9 can repress U87 cell proliferation. Journal of Cellular and Molecular Medicine. 2017 Jun 19. doi: 10.1111/jcmm.13236. (IF= 4.499, SCI二区)

3. Peng, L., P. Wang, L. Li, C. Xu, J. Liu, X. Guo, D. He, H. Huang, Z. Cheng. Exomic and Epigenomic Analyses of Monozygotic Twins Discordant for Cryptorchidism. Twin Research and Human Genetics. 2017 Jun 13:1-6. doi: 10.1017/thg.2017.33. (IF= 1.314, SCI四区)

4. Wei, W., X. Ji, X. Guo, S. Ji. Regulatory role of N6-methyladenosine (m6A) methylation in RNA processing and human diseases. Journal of Cellular Biochemistry. 2017 Mar 3. doi: 10.1002/jcb.25967. (IF= 3.085, SCI三区)

5. An, Y., H. Wang, J. Jie, Y. Tang, W. Zhang, S. Ji, X. Guo. Identification of distinct molecular subtypes of uterine carcinosarcoma. Oncotarget. 2017 Feb 2. doi: 10.18632/oncotarget.15032 (Top) (Corresponding Author) (IF= 5.168, SCI一区)

6. Dalerba P.,D.Sahoo, S. Paik, X. Guo, G. Yothers, N. Song, N. Wilcox-Fogel, E. Forgó, P.S. Rajendran, S.P. Miranda, S. Hisamori, J. Hutchison, T. Kalisky, D. Qian, N. Wolmark, G.A. Fisher, M. van de Rijn, M.F. Clarke, CDX2 as a Prognostic Biomarker in Stage II and Stage III Colon Cancer. New England Journal of Medicine, 2016. 374(3):211-22. (Top) (IF= 72.406, SCI一区)

7. Gao S., R. Liu, Zhao, Y., P. Wang, D.G. Ward, G. Wang, X. Guo, G. Gu, W. Niu, T. Zhang, A. Martin, Z. Guo, X. Feng, Y Qi, Y. Ma, Integrative topological analysis of mass spectrometry data reveals molecular features with clinical relevance in esophageal squamous cell carcinoma. Sci Rep., 2016.22(6):21586. (IF= 4.259, SCI二区)

8. Guo, X., S. Su, G. Skogerboe, W. Li, Z. Li, S. Zhang, S. Chen, R. Chen. Differential expression of miRNAs related to caste differentiation in the honey bee, Apis mellifera. Apidologie, 2016. 47:495-508. (IF= 2.196, SCI四区)

9. Guo, X., V.Y. Jo, A. Mills, S. Zhu, C.H. Lee, I. Espinosa, M.R. Nucci, S. Varma, E. Forgo, T. Hastie, S. Anderson, K. Ganjoo, A.H. Beck, R. West, C. Fletcher, and M. van de Rijn, Clinically relevant molecular subtypes in leiomyosarcoma. Clin Cancer Res, 2015. 21(15): p.3501-11. (Top)(IF= 9.619, SCI一区)

10. Guo, X., E. Forgo and M. van de Rijn, Molecular subtyping of leiomyosarcoma with 3' end RNA sequencing. Genomics Data, 2015. 5: 366-367.

11. Demicco, E.G., G.M. Boland, K.J. Brewer Savannah, K. Lusby, E.D. Young, D. Ingram, K.L. Watson, M. Bailey, X. Guo, J.L. Hornick, M. van de Rijn, W.L. Wang, K.E. Torres, D. Lev, and A.J. Lazar, Progressive Loss Of Myogenic Differentiation In Leiomyosarcoma Has Prognostic Value. Histopathology, 2015. 66(5):627-38. (IF= 3.523, SCI二区)

12. Wang, Y., A. Marino-Enriquez, R.R. Bennett, M. Zhu, Y. Shen, G. Eilers, J.C. Lee, J. Henze, B.S. Fletcher, Z. Gu, E.A. Fox, C.R. Antonescu, C.D. Fletcher, X. Guo, C.P. Raut, G.D. Demetri, M. van de Rijn, T. Ordog, L.M. Kunkel, and J.A. Fletcher, Dystrophin is a tumor suppressor in human cancers with myogenic programs. Nat Genet, 2014. 46(6): p. 601-6.(Top) (IF= 27.959, SCI一区)

13. Brunner, A.L.*, J. Li*, X. Guo, R.T. Sweeney, S. Varma, S.X. Zhu, R. Li, R. Tibshirani, and R.B. West, A shared transcriptional program in early breast neoplasias despite genetic and clinical distinctions. Genome Biol, 2014. 15(5): p. R71. (Top) (IF= 11.908, SCI一区)

14. van de Rijn, M., X. Guo, R.T. Sweeney, A.H. Beck, and R.B. West, Molecular Pathological Analysis of Sarcomas Using Paraffin-Embedded Tissue: Current Limitations and Future Possibilities. Histopathology, 2014. 64(1): 163-70. (IF= 3.523, SCI二区)

15. Guo, X., S.X. Zhu, A.L. Brunner, M. van de Rijn, and R.B. West, Next generation sequencing-based expression profiling identifies signatures from benign stromal proliferations that define stromal components of breast cancer. Breast Cancer Res, 2013. 15(6): p. R117. (IF= 6.345, SCI二区)

16. Guo, X., S. Su, G. Skogerboe, S. Dai, W. Li, Z. Li, F. Liu, R. Ni, Y. Guo, S. Chen, S. Zhang, and R. Chen, Recipe for a Busy Bee: MicroRNAs in Honey Bee Caste Determination. PLOS ONE, 2013. 8(12): p. e81661. (IF= 2.806, SCI三区)

17. Newburger, D.E., D. Kashef-Haghighi, Z. Weng, R. Salari, R.T. Sweeney, A.L. Brunner, S.X. Zhu, X. Guo, S. Varma, M.L. Troxell, R.B. West, S. Batzoglou, and A. Sidow, Genome Evolution during Progression to Breast Cancer. Genome Res, 2013. 23(7):1097-108.(Top) (IF= 11.922, SCI一区)

18. Lee, C.H., W.B. Ou, A. Marino-Enriquez, M. Zhu, M. Mayeda, Y. Wang, X. Guo, A.L. Brunner, F. Amant, C.A. French, R.B. West, J.N. McAlpine, C.B. Gilks, M.B. Yaffe, L.M. Prentice, A. McPherson, S.J. Jones, M.A. Marra, S.P. Shah, M. van de Rijn, D.G. Huntsman, P. Dal Cin, M. Debiec-Rychter, M.R. Nucci, and J.A. Fletcher, 14-3-3 fusion oncogenes in high-grade endometrial stromal sarcoma. Proc Natl Acad Sci U S A, 2012. 109(3): p. 929-34.(Top) (IF= 9.661, SCI一区)

19. Brunner, A.L., A.H. Beck, B. Edris, R.T. Sweeney, S.X. Zhu, R. Li, K. Montgomery, S. Varma, T. Gilks, X. Guo, J.W. Foley, D.M. Witten, C.P. Giacomini, R.A. Flynn, J.R. Pollack, R. Tibshirani, H.Y. Chang, M. van de Rijn, and R.B. West, Transcriptional profiling of long non-coding RNAs and novel transcribed regions across a diverse panel of archived human cancers. Genome Biol, 2012. 13(8): p. R75. (Top) (IF= 11.908, SCI一区)

20. Li, M.*, S. Wen*, X. Guo, B. Bai, Z. Gong, X. Liu, Y. Wang, Y. Zhou, X. Chen, L. Liu, and R. Chen, The novel long non-coding RNA CRG regulates Drosophila locomotor behavior. Nucleic Acids Res, 2012. 40(22): p. 11714-27. (Top) (IF= 10.162, SCI一区)

21. Lee, C.H., R.H. Ali, M. Rouzbahman, A. Marino-Enriquez, M. Zhu, X. Guo, A.L. Brunner, S. Chiang, S. Leung, N. Nelnyk, D.G. Huntsman, C. Blake Gilks, T.O. Nielsen, P. Dal Cin, M. van de Rijn, E. Oliva, J.A. Fletcher, and M.R. Nucci, Cyclin D1 as a diagnostic immunomarker for endometrial stromal sarcoma with YWHAE-FAM22 rearrangement. Am J Surg Pathol, 2012. 36(10): p. 1562-70. (IF= 5.363, SCI二区)

22. Wan, L.C.*, F. Wang*, X. Guo, S. Lu, Z. Qiu, Y. Zhao, H. Zhang, and J. Lin, Identification and characterization of small non-coding RNAs from Chinese fir by high throughput sequencing. BMC Plant Biol, 2012. 12: p. 146. (IF= 3.964, SCI三区)

23. Li, D., Y. Wang, K. Zhang, Z. Jiao, X. Zhu, G. Skogerboe, X. Guo, V. Chinnusamy, L. Bi, Y. Huang, S. Dong, R. Chen, and Y. Kan, Experimental RNomics and genomic comparative analysis reveal a large group of species-specific small non-message RNAs in the silkworm Bombyx mori. Nucleic Acids Res, 2011. 39(9): p. 3792-805. (Top) (IF= 10.162, SCI一区)

24. Huang, W., X. Guo, J. Dai, and R. Chen, MicroRNA and lncRNA in Neurodegenerative Diseases. Progress in Biochemistry and Biophysics, 2010. 37(8): p. 8. (IF= 0.341, SCI四区)

25. Shi, B*., X. Guo*, T. Wu*, S. Sheng, J. Wang, G. Skogerbo, X. Zhu, and R. Chen, Genome-scale identification of Caenorhabditis elegans regulatory elements by tiling-array mapping of DNase I hypersensitive sites. BMC Genomics, 2009. 10: p. 92. (*, co-first-author) (IF= 3.729, SCI二区)

26. Tan, Y., B. Zhang, T. Wu, G. Skogerbo, X. Zhu, X. Guo, S. He, and R. Chen, Transcriptional inhibiton of Hoxd4 expression by miRNA-10a in human breast cancer cells. BMC Mol Biol, 2009. 10: p. 12. (IF= 1.939, SCI三区)

五、出版著作:

1. Cheng-Han Lee, Inigo Espinosa, Xiangqian Guo, Matt van de Rijn. Molecular Profiling of sarcomas. Sarcoma Oncology: A Multidisciplinary Approach. People’s Medical Publishing House – USA, 2016 01 Jul. ISBN10:1607950170. (Chapter)

六、讲授课程:

医学生物信息学、医学统计学上机